Research

Abstract: Manipulation of Large Vessel Occlusion Models Demonstrates Pathophysiological Heterogeneity

Stony Brook University

2024 - 2024

The research investigates the heterogeneity of ischemic stroke using two preclinical models: the Longa and Koizumi models. These models simulate varying degrees of stroke severity and reperfusion, as well as highlight the differences in cerebral blood flow, neutrophil infiltration, and functional deficits between these models, offering insights into patient heterogeneity in stroke progression and treatment efficacy.

Role: Co-author, contributed to data analysis by sorting behavioral videos to establish a laterality index.

Authors: Laurel E. Schappell, Eleftherios A. Zoumpanidopoulos, Claire Polizu, Meiyi Tang PhD, James Dipersio, Stella E. Tsirka PhD, Neil A. Nadkarni MD

Genotyping on Mice Colonies

Stony Brook University

2023 - Today

Performed genotyping to identify and properly categorize our mice colonies. This process is essential for ensuring the accurate selection of genetically modified mice for our experiments, which is crucial in for their use in our research due to the different reporter gene of each mice colony as well as to ensure that the mice tested are genetically similar. The process involves standard PCR assays designed to detect the presence of this fluorescent protein.